Ian L Megson Selected Research

hydroxyguanidine

2/2013

A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation.

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Ian L Megson Research Topics

Disease

9	Cardiovascular Diseases (Cardiovascular Disease) 01/2017 - 05/2002
6	Atherosclerosis 01/2022 - 03/2005
6	Inflammation (Inflammations) 12/2018 - 03/2005
4	Thrombosis (Thrombus) 01/2016 - 01/2003
4	Schizophrenia (Dementia Praecox) 01/2013 - 04/2009
2	Coronary Artery Disease (Coronary Atherosclerosis) 01/2020 - 08/2010
2	Acute Coronary Syndrome 12/2018 - 06/2015
2	Type 2 Diabetes Mellitus (MODY) 05/2015 - 05/2014
2	Disease Progression 01/2015 - 05/2002
2	Myocardial Infarction 01/2015 - 01/2013
2	Necrosis 08/2014 - 07/2008
2	Pneumonia (Pneumonitis) 10/2013 - 04/2012
2	Acute Kidney Injury (Acute Renal Failure) 07/2013 - 02/2013
2	Chronic Obstructive Pulmonary Disease (COPD) 09/2008 - 03/2008
1	Pulmonary Hypertension 01/2022
1	Arteriosclerosis 01/2022
1	Spasm (Spasms) 01/2020
1	COVID-19 01/2020
1	Organophosphate Poisoning 01/2020
1	Poisoning 01/2020
1	Neuroblastoma 05/2019
1	Alzheimer Disease (Alzheimer's Disease) 05/2019
1	Overweight 01/2019
1	ST Elevation Myocardial Infarction 06/2015
1	Hypertension (High Blood Pressure) 01/2015
1	Cystic Fibrosis (Mucoviscidosis) 02/2014
1	Neoplasms (Cancer) 08/2013
1	Chronic Renal Insufficiency 02/2012
1	Lung Injury 09/2011
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 09/2011

Drug/Important Bio-Agent (IBA)

8	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2020 - 05/2002
6	AntioxidantsIBA 01/2020 - 12/2005
4	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2013
4	AntibodiesIBA 12/2018 - 04/2009
4	oxidized low density lipoproteinIBA 12/2018 - 01/2015
3	EnzymesIBA 01/2020 - 12/2005
3	Immunoglobulin G (IgG)IBA 12/2018 - 01/2015
2	Acetylcysteine (Siran)FDA LinkGeneric 01/2020 - 02/2012
2	Proteins (Proteins, Gene)FDA Link 01/2020 - 06/2015
2	ApolipoproteinsIBA 12/2018 - 01/2015
2	AntigensIBA 12/2018 - 06/2015
2	Superoxides (Superoxide)IBA 08/2014 - 01/2011
2	MetalsIBA 08/2014 - 04/2012
2	IonsIBA 10/2013 - 04/2012
2	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 10/2009 - 03/2003
1	Parasympatholytics (Antispasmodics)IBA 01/2020
1	Vasodilator Agents (Vasodilators)IBA 01/2020
1	Nitroglycerin (Dynamite)FDA LinkGeneric 01/2020
1	Angiotensin-Converting Enzyme 2IBA 01/2020
1	InsecticidesIBA 01/2020
1	Malondialdehyde (Propanedial)IBA 01/2020
1	Sulfhydryl Compounds (Thiols)IBA 01/2020
1	LigandsIBA 05/2019
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 05/2019
1	vanillinIBA 05/2019
1	LDL Lipoproteins (beta Lipoproteins)IBA 12/2018
1	Peptides (Polypeptides)IBA 12/2018
1	PolyphenolsIBA 01/2017
1	XenobioticsIBA 01/2017
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 06/2016
1	LipidsIBA 06/2016
1	CholesterolIBA 06/2016
1	iodixanol (Visipaque)FDA Link 01/2016
1	Iohexol (Omnipaque)FDA Link 01/2016
1	Apolipoproteins B (ApoB)IBA 06/2015
1	Glucose (Dextrose)FDA LinkGeneric 05/2015
1	Hypoglycemic Agents (Hypoglycemics)IBA 05/2015
1	Insulin (Novolin)FDA Link 05/2015
1	HDL CholesterolIBA 01/2015
1	Apolipoproteins AIBA 01/2015
1	Free RadicalsIBA 08/2014
1	Fibrinogen (Factor I)FDA Link 05/2014
1	Matrix Metalloproteinases (MMPs)IBA 05/2014
1	Thromboplastin (Tissue Factor)IBA 05/2014
1	P-SelectinIBA 05/2014
1	DisulfidesIBA 02/2014
1	Therapeutic UsesIBA 02/2014
1	Glycoproteins (Glycoprotein)IBA 02/2014
1	Cysteine (L-Cysteine)FDA Link 02/2014
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 08/2013
1	Docosahexaenoic AcidsIBA 08/2013
1	Eicosapentaenoic AcidIBA 08/2013
1	Nitric Oxide DonorsIBA 07/2013
1	RoscovitineIBA 04/2013
1	Cyclin-Dependent Kinases (cdk Proteins)IBA 04/2013
1	ProdrugsIBA 02/2013
1	hydroxyguanidineIBA 02/2013
1	gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)IBA 02/2013
1	SmokeIBA 01/2013
1	HLA-DRB1 Chains (HLA DRB1)IBA 01/2013
1	OxidesIBA 04/2012
1	AcidsIBA 04/2012
1	Immunoglobulin E (IgE)IBA 09/2011
1	Zinc Oxide FDA Link 09/2011
1	Transforming Growth Factors (Transforming Growth Factor)IBA 09/2011

Therapy/Procedure

2	Stents 01/2022 - 01/2003
2	Percutaneous Coronary Intervention 01/2020 - 01/2003
1	Transcutaneous Electric Nerve Stimulation (TENS) 01/2020
1	Therapeutics 06/2016
1	Injections 05/2015